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However, it should be recognized that the vast majority of controlled data regarding second-line therapies pertains to the situation in which anti-TNF therapy is used as first-line advanced therapy, and one of the other classes of therapy is used as second- or third-line therapy

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Occlusion of the MCA was confirmed when a sudden drop in CBF was observed on the Doppler, confirming MCAO and the start of ischaemia

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